第1178回 生物科学セミナー
Presentator:John B. Hogenesch
Cincinnati Children’s Hospital Medical Center
Title:Time for circadian medicine: from molecular outputs to better therapeutics
Day:平成29年11月22日(水)15:30〜16:40
The past several decades has seen an explosion of growth in mechanistic understanding of circadian clocks in several model organisms including humans. However, translation of that knowledge into actionable medical interventions has been slow to non-existent. Here, I will discuss some of the reasons why this is and our efforts to mitigate this using systems biology approaches. I will talk about our recent progress in understanding the molecular output of the clock in the mouse and humans, including identifying new opportunities for circadian dosing time in improving drug action -- hypothesis-driven, mechanistic circadian medicine. I will talk about our efforts to test these hypothesis prospectively in model organisms and retrospectively in large clinical databases. Finally, I will discuss future opportunities and challenges. References: Zhang, Lahens, et al., PNAS, 111(45): 16219-16224, 2014 Anafi et al., PNAS, 114(20): 5312-5317, 2017
References
Zhang, Lahens, et al., PNAS, 111(45): 16219-16224, 2014 Anafi et al., PNAS, 114(20): 5312-5317, 2017

世話人:理学系研究科 深田 吉孝