第1219回 生物科学セミナー
演者: Prof. Steven A. Brown
University of Zürich, Switzerland
演題:Nuclear reorganizations controlling sleep and metabolism
日時:平成30年05月31日(木)16:30〜18:00
In cortex, an extensive transcriptional program driven by circadian and sleep-wake-dependent neuronal activity is important to reprogram synaptic function and cellular metabolism across day and night. We find that novel membrane-less nuclear structures containing members of the DBHS (Drosophila Behavior, Human Splicing) protein family are essential to achieve this transcriptional program at a cellular level, and in turn to potentiate sleep slow waves at a network level. These “neurospeckles” are driven by circadian and sleep-wake-dependent neuronal firing in a pathway employing mainly mGluR5 and Protein Kinase C, and are important for sleep gene expression and the homeostatic response to sleep deprivation. Surprisingly, in liver very similar speckles are driven by feeding cycles, and serve to optimize metabolic transcriptional programs. Thus, our results identify DBHS protein clusters as dynamic, intra-nuclear structures important for regulation of diverse tissue-specific transcriptional programs.


世話人:理学系研究科 深田 吉孝

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