第1219回 生物科学セミナー
演者: Prof. Steven A. Brown
University of Zürich, Switzerland
演題:Nuclear reorganizations controlling sleep and metabolism
日時:平成30年05月31日(木)16:30〜18:00
In cortex, an extensive transcriptional program driven by circadian and
sleep-wake-dependent neuronal activity is important to reprogram synaptic
function and cellular metabolism across day and night. We find that novel
membrane-less nuclear structures containing members of the DBHS (Drosophila
Behavior, Human Splicing) protein family are essential to achieve this
transcriptional program at a cellular level, and in turn to potentiate sleep slow
waves at a network level. These “neurospeckles” are driven by circadian and
sleep-wake-dependent neuronal firing in a pathway employing mainly mGluR5
and Protein Kinase C, and are important for sleep gene expression and the
homeostatic response to sleep deprivation. Surprisingly, in liver very similar
speckles are driven by feeding cycles, and serve to optimize metabolic
transcriptional programs. Thus, our results identify DBHS protein clusters as
dynamic, intra-nuclear structures important for regulation of diverse
tissue-specific transcriptional programs.
世話人:理学系研究科 深田 吉孝
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