第1306回 生物科学セミナー
演者: Prof. Erik Herzog
(Department of Biology, Washington University, MO USA)
演題:What wakes us: Networked circadian clocks in the brain
日時:平成30年10月10日(木)17:00〜18:30
On a daily basis, organisms must anticipate the challenges of the cycle of light-dark,
warm-cold, food and starvation. Circadian clocks are ubiquitous across species and cell types.
This talk will review the evidence for intrinsic circadian timing in the neurons and glia of the
mammalian brain. The focus will be on how these cells synchronize to each other and to the
local light-dark cycle. The latest advances in our ability to record and manipulate gene and
protein expression, neuronal and glial activity, real-time recording in vivo and in vitro set the
stage for us to map the network of connected circadian clocks in the brain.
References
1) Jones JR, Simon T, Lones L, Herzog ED., “SCN VIP Neurons Are Essential for Normal
Light-Mediated Resetting of the Circadian System.” J. Neurosci., 38(37): 7986-7995 (2018).
2) Mazuski C, Abel JH, Chen SP, Hermanstyne TO, Jones JR, Simon T, Doyle FJ 3rd, Herzog
ED., “Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide
Release of VIP SCN Neurons.” Neuron, 99(3): 555-563.e5 (2018).
世話人:理学系研究科 深田 吉孝