第1306回 生物科学セミナー
演者: Prof. Erik Herzog
(Department of Biology, Washington University, MO USA)
演題:What wakes us: Networked circadian clocks in the brain
日時:平成30年10月10日(木)17:00〜18:30
On a daily basis, organisms must anticipate the challenges of the cycle of light-dark, warm-cold, food and starvation. Circadian clocks are ubiquitous across species and cell types. This talk will review the evidence for intrinsic circadian timing in the neurons and glia of the mammalian brain. The focus will be on how these cells synchronize to each other and to the local light-dark cycle. The latest advances in our ability to record and manipulate gene and protein expression, neuronal and glial activity, real-time recording in vivo and in vitro set the stage for us to map the network of connected circadian clocks in the brain. References 1) Jones JR, Simon T, Lones L, Herzog ED., “SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System.” J. Neurosci., 38(37): 7986-7995 (2018). 2) Mazuski C, Abel JH, Chen SP, Hermanstyne TO, Jones JR, Simon T, Doyle FJ 3rd, Herzog ED., “Entrainment of Circadian Rhythms Depends on Firing Rates and Neuropeptide Release of VIP SCN Neurons.” Neuron, 99(3): 555-563.e5 (2018).


世話人:理学系研究科 深田 吉孝